Overview
Neuroscience is entering a new era, with Brain-on-a-Chip organoids redefining how we model the human brain. Adoption, however, has been slowed by variability, fragile long-term cultures, and the lack of scalable tools for functional readout.
Each challenge is solvable — and the breakthrough lies in moving beyond fragmented fixes toward a unified, integrated platform that delivers mature, reliable organoids at scale, unlocking a new era of precision drug development.
LithopsBio tackles variability, viability, and validation
— removing adoption barriers at scale.
AUTOMATION
Minimize technical variability and unlock scalable workflows
MICROFLUIDICS
Enhance oxygenation, tissue health, and maturation
MONITORING
Track neural activity and culture conditions in real time
Deep-Tech
NIH support has enabled the development of advanced electrophysiology tools that transform “monitoring” from a concept into a scalable reality. These innovations integrate seamlessly with organoid culture systems, providing high‑density, long‑term recordings of neural activity.
Willow | Ultra-high channel count neurophysiology
ASIC | Neurosensing IC
MEMS | Silicon probe
Validation
Cell diversity and network dynamics in photosensitive human brain organoids
Publications
- Quadrato G., Nguyen T., Macosko EZ., Sherwood JL., Yang SM., Berger DR., Maria N., Scholvin J., Goldman M., Kinney JP., Boyden ES., Lichtman JW., Williams ZM., McCarroll SA., Arlotta P. “Cell diversity and network dynamics in photosensitive human brain organoids..” Nature , 545 , 2017.