Overview
Neuroscience is entering a new era, with Brain-on-a-Chip organoids redefining how we model the human brain. Adoption, however, has been slowed by variability, fragile long-term cultures, and the lack of scalable tools for functional readout.
Each challenge is solvable — and the breakthrough lies in moving beyond fragmented fixes toward a unified, integrated platform that delivers mature, reliable organoids at scale, unlocking a new era of precision drug development.
LithopsBio tackles variability, viability, and validation
— removing adoption barriers at scale.
AUTOMATION
Minimize technicalvariability and unlockscalable workflows
MICROFLUIDICS
Enhance oxygenation,tissue health, andmaturation
MONITORING
Track neural activityand culture conditions in real time
Deep-Tech
NIH support has enabled the development of advanced electrophysiology tools that transform “monitoring” from a concept into a scalable reality. These innovations integrate seamlessly with organoid culture systems, providing high‑density, long‑term recordings of neural activity.
Willow | Ultra-high channel count neurophysiology
ASIC | Neurosensing IC
MEMS | Silicon probe
Validation
Cell diversity and network dynamics in photosensitive human brain organoids
Publications
- Quadrato, G., Nguyen, T., Macosko, E.Z., Sherwood, J.L., Min Yang, S., Berger, D.R., Maria, N., Scholvin, J., Goldman, M., Kinney, J.P., and Boyden, E.S. “Cell diversity and network dynamics in photosensitive human brain organoids.” Nature, 545(7652), pp.48–53, 2017.
- Allen, B.D., Moore-Kochlacs, C., Bernstein, J.G., Kinney, J.P., Scholvin, J., Seoane, L.F., Chronopoulos, C., Lamantia, C., Kodandaramaiah, S.B., Tegmark, M., and Boyden, E.S. “Automated in vivo patch-clamp evaluation of extracellular multielectrode array spike recording capability.” Journal of Neurophysiology, 120(5), pp.2182–2200, 2018.
- Murray Carpenter. "Glut of data from mice brains tests MIT’s computing power." Boston Globe. January 31, 2016.
- Jörg Scholvin, et al. “Close-Packed Silicon Microelectrodes for Scalable Spatially Oversampled Neural Recording.” IEEE Xplore Digital Library, February 24, 2015.
- Justin P. Kinney, et al. “A direct-to-drive neural data acquisition system.” Frontiers in Neural Circuits, September 1, 2015.